| Name | Birth date | Birth location | Death date | Death location | Marriage date | Marriage location | Spouse |
| Sample, Evajoe | Abt 1945 | | | | Abt 1980 | | Margraves, Charles Edd |
| Sauls, Lillie Maude | September 10, 1915 | | | | | | Ard, Manuel Hartwald |
| Schroder, Lula Dell | March 1930 | Jacksonville, Duval CO., FL. | | | Abt 1959 | Jacksonville, Duval CO., FL. | Ard, Carl LaVern |
| Seacat, Benjamin D. | Abt 1810 | Montgomery CO., VA. | Unknown | | February 16, 1833 | Montgomery CO., VA. | Holmes, Permelia |
| Segui, Cheryle Lynn | February 02, 1964 | | | | June 22, 1985 | Kingsland, Camden CO., GA | Spence, Franklin Windell |
| Simmons, Unknown | | | | | | | Margraves, Jessy |
| Smith, Ann | January 25, 1935 | | September 21, 1992 | Los Angles, Orange, CA | | | Spence, Orvel Gene |
| Spence, Alpha F. | February 07, 1886 | Owsley CO., KY. | July 28, 1925 | Owsley CO., KY. | | | |
| Spence, Amanda M. | April 10, 1842 | Pulaski CO., VA. | Unknown | | | | |
| Spence, Andrew P. | February 27, 1878 | Owsley CO., KY. | December 1958 | Owsley CO., KY. | | | |
| Spence, Beatrice Edith | December 05, 1924 | Beattyville Lee Co. KY | | | Abt 1945 | Beattyville Lee Co. KY | Teater, William Aaron |
| Spence, Bethel V. | December 21, 1931 | | | | | | Warner, Junior |
| Spence, Calvin C. | April 10, 1925 | | | | | | |
| Spence, Carol L. | February 24, 1876 | Owsley CO., KY. | Unknown | Owsley CO., KY. | | | |
| Spence, Charlie F. | November 16, 1918 | | | | | | |
| Spence, Cynthia Ann | June 29, 1958 | Key West, Monroe CO., FL | | | May 27, 1990 | Jacksonville, Duval CO., FL. | Wimberly, Henry III |
| Spence, Denzil E. | December 07, 1922 | Owsley CO., KY. | July 1996 | Tyner, Jackson CO., KY | | | |
| Spence, Elby N. | September 19, 1912 | | November 12, 1983 | Owsley Co., KY | | | |
| Spence, Elvira M. | June 02, 1840 | Pulaski CO.,VA. | Unknown | | | | |
| Spence, Erasmus M. | December 29, 1855 | Owsley Co., KY | Unknown | | | | |
| Spence, Franklin F. | July 15, 1881 | Owsley CO., KY. | Unknown | ? | | | |
| Spence, Franklin Windell | August 26, 1961 | Key West, Monroe Co, FL | | | January 12, 1982 | Jacksonville, Duval Co, FL. | Phillips, Terri Jolene |
| Spence, Fred Herman | August 24, 1966 | | | | | | |
| Spence, Fredrick Herman | November 19, 1897 | Owsley CO., KY. | April 03, 1950 | Richmond, Madison CO., KY | Abt 1922 | Owsley Co., KY | Margraves, Della Edith |
| Spence, George L. | October 24, 1883 | Owsley CO., KY. | January 19, 1956 | Owsley CO., KY. | | | ??? Spence, Emily |
| Spence, Heber Wilson | December 10, 1927 | Beattyville Lee Co. KY | | | Abt 1950 | Beattyville Lee Co. KY | Coomer, Wanda Lee |
| Spence, Henry C. | August 02, 1874 | Owsley CO., KY. | September 12, 1958 | Owsley CO., KY. | August 04, 1910 | Delvania, Lee CO., KY. | Marcum, Florence |
| Spence, Herman Windell | July 19, 1935 | Beattyville, Lee CO., KY. | | | April 26, 1969 | Kingsland, Camden CO., GA | Ard, Betty LaVaughn |
| Spence, Irvine Clay | April 29, 1911 | | April 08, 1984 | KY | | | |
| Spence, James A. | January 02, 1916 | | August 04, 1986 | KY | | | |
| Spence, James B. | March 18, 1850 | Pulaski CO., VA. | February 28, 1919 | Owsley CO., KY. | Abt 1874 | Owsley CO., KY. | Mayes, Sarah E. |
| Spence, Janea Elizebeth | December 27, 1844 | Pulaski CO., VA. | Unknown | | | | |
| Spence, Jimmy Lee | September 25, 1950 | | | | | | |
| Spence, John | Bef 1790 | | Unknown | | | | |
| Spence, John Sherman | March 10, 1891 | Owsley CO., KY. | December 21, 1978 | Owsley CO., KY. | | | |
| Spence, Jonathan Hammet | January 30, 1854 | Owsley County, KY | Unknown | | | | |
| Spence, Jonathan W. | August 22, 1812 | Montgomery CO., VA. | March 15, 1871 | Owsley CO., KY. | July 28, 1835 | Montgomery CO., VA | Holmes, Mary |
| Spence, Judy | May 26, 1953 | | | | | | |
| Spence, Katherine Louise | September 24, 1988 | | | | | | |
| Spence, Linda | July 17, 1967 | | | | | | |
| Spence, Lucy E. | April 04, 1890 | Owsley CO., KY. | Unknown | Owsley CO., KY. | | | |
| Spence, Lynette Marie | June 12, 1965 | | | | | | |
| Spence, Mary A. | March 24, 1850 | Pulaski CO.,VA. | Unknown | | | | |
| Spence, Mary E. | November 16, 1893 | Owsley CO., KY. | Aft November 16, 1893 | Owsley CO., KY. | | | |
| Spence, Mazzine S. | October 11, 1879 | Owsley CO., KY. | Unknown | Owsley CO., KY. | | | |
| Spence, Melissa Sue | July 25, 1982 | Jacksonville, Duval Co, FL | | | | | |
| Spence, Mollie Florence | February 06, 1895 | Owsley CO., KY. | December 05, 1985 | Owsley CO., KY. | | | Wilson, Unknown |
| Spence, Mollie Ruth | April 22, 1938 | Beattyville Lee Co. KY | | | | | Dehart, Harold Gene |
| Spence, Nannie Grace | May 13, 1914 | | | | | | |
| Spence, Nathaniel D. | March 26, 1846 | Pulaski CO., VA. | Unknown | | | | |